Syphilis
Caused by treponema pallidum
Transmitted through sexual contact and transplantatly.
Caused by treponema pallidum
Transmitted through sexual contact and transplantatly.
Clinical stages of syphilis
Primary -
After exposure with pathogen a papule develop at site of inoculation
Painless firm chancre
Regional lymphadenopathy
Healing occur spontaneously within 2-3weeks.
Primary -
After exposure with pathogen a papule develop at site of inoculation
Painless firm chancre
Regional lymphadenopathy
Healing occur spontaneously within 2-3weeks.
Investigation
Darkfield microscopy
Raised antibody titer
Darkfield microscopy
Raised antibody titer
Treatment
penicillin g Benzathine 2.4million international unit (iu)-gluteal region
Intramuscular 💉
Doxycycline 100mg twice a day for 2 week in penicillin allergic patient.
penicillin g Benzathine 2.4million international unit (iu)-gluteal region
Intramuscular 💉
Doxycycline 100mg twice a day for 2 week in penicillin allergic patient.
Secondary -
4-10week after appearance of primary lesions
Constitutional symptoms develope with fever
Malaise
Sore throat
Arthralgia
4-10week after appearance of primary lesions
Constitutional symptoms develope with fever
Malaise
Sore throat
Arthralgia
Patient may develop nephritis, arthritis, hepatitis, meningitis
Untreated early symptoms causes Fetal infection in pregnant woman and also still birth of baby.
Untreated early symptoms causes Fetal infection in pregnant woman and also still birth of baby.
O/E -
Generalised lymphadenopathy
Generalised skin rash whole body including palm and sole but not face.
Condylomata Lata -watery plaque like lesions found at perianal area and other moist body parts.
Acute neurological sign - aseptic meningitis, cranial nerves palsy
Generalised lymphadenopathy
Generalised skin rash whole body including palm and sole but not face.
Condylomata Lata -watery plaque like lesions found at perianal area and other moist body parts.
Acute neurological sign - aseptic meningitis, cranial nerves palsy
Investigation
Serological test
Cutaneous and mucous membrane also show traponema palladium on darkfield 🔬 microscopy .
There is evidence of hepatitis and nephritis.
Transient CSF pleocytosis seen in 30-70% cases.
Treatment same as primary if there is no involvement of cns.
Serological test
Cutaneous and mucous membrane also show traponema palladium on darkfield 🔬 microscopy .
There is evidence of hepatitis and nephritis.
Transient CSF pleocytosis seen in 30-70% cases.
Treatment same as primary if there is no involvement of cns.
Tertiary -
This occur any time after secondary
Occur at Years of latency.
Seen in 1/3 in untreated.
Characterised by :-
Localised gummatous lesions -
Granulomatous lesions.
Anywhere
Gumma found in testis, skull, tibia, liver, clavicle, fibula
This occur any time after secondary
Occur at Years of latency.
Seen in 1/3 in untreated.
Characterised by :-
Localised gummatous lesions -
Granulomatous lesions.
Anywhere
Gumma found in testis, skull, tibia, liver, clavicle, fibula
Diffuse inflammation -in CNS and large arteries
Aortic aneurysm
Aortic regurgitation
Aortitis
Neurosyphilis as subacute meningitis, intracranial mass, paraparesis tabes dorsalis general paralysis of insane.
Aortic aneurysm
Aortic regurgitation
Aortitis
Neurosyphilis as subacute meningitis, intracranial mass, paraparesis tabes dorsalis general paralysis of insane.
Treatment -
Benzyl penicillin 3-4 million units 4 hourly for 10-14 days.
Benzyl penicillin 3-4 million units 4 hourly for 10-14 days.
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